Chimeric varicella zoster virus virus-like particles
The present invention discloses novel chimeric Varicella Zoster Virus (VZV) virus-like particles (VLPs) comprising chimeric VZV glycoproteins. The invention also discloses vaccine formulations of the...
View ArticleAnti-viral pyrimidine nucleoside analogues
A compound of formula (I) wherein Ar can be one six-membered or two fused six-membered aromatic rings; R8 and R9 can be hydrogen, alkyl, cycloalkyl, halogens, amino, alkylamino, dialkylamino, nitro,...
View ArticleVaccine against varicella zoster virus
Use of an immunogenic composition comprising VZV gE, or immunogenic fragment thereof, and a TH-1 adjuvant in the preparation of a medicament for the prevention or amelioration of shingles and/or post...
View ArticleVaccine against varicella zoster virus
Use of an immunogenic composition comprising VZV gE, or immunogenic fragment thereof, and a TH-1 adjuvant in the preparation of a medicament for the prevention or amelioration of shingles and/or post...
View ArticlePreventing or treating viral infection using an inhibitor of the lsd1...
An embodiment of the invention provides preventing or treating a viral infection of a host, comprising administering to the host an effective amount of an inhibitor of the protein LSD1 and/or a...
View ArticleMethods for the diagnosis of varicella zoster virus infection
The present invention relates to methods and devices for the rapid assessment of saliva for the presence of varicella zoster virus (VZV) particles. The methods and devices permit rapid, simple and...
View ArticleInactivated varicella zoster virus vaccines, methods of production, and uses...
The invention provides an inactivated varicella zoster virus (VZV), and compositions and vaccines comprising said inactivated VZV, wherein the infectivity of the VZV is undetectable and wherein the...
View ArticleAnti-viral pyrimidine nucleoside derivatives
A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula (II):...
View ArticleMethod of treating herpes virus infection using macrocyclic lactone compound
A method of treating herpes simplex virus infection or varicella zoster virus infection is disclosed. The method includes topically applying a composition containing an effective amount of one or more...
View ArticleMethod of preparation of antiviral compounds and useful intermediates thereof
The invention is directed to processes for synthesizing bicyclic nucleoside antiviral compounds and for synthesizing the intermediates used in the process. The invention is also directed to novel...
View ArticleAnti-viral pyrimidine nucleoside analogues
A compound of formula (I) wherein Ar can be one six-membered or two fused six-membered aromatic rings; R8 and R9 can be hydrogen, alkyl, cycloalkyl, halogen, amino, alkylamino, dialkylamino, nitro,...
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